Table 4.
Summary of Findings for Critical and Important Study Outcomes.
| Outcomes (Importance) | Participants (Studies), n | Certainty of Evidence (GRADE) | RR (95% CI) | ARD with Intervention |
|---|---|---|---|---|
| Defibrillation dose < 1.5 J/kg (I) compared to defibrillation dose approximating 2 J/kg (C) for defibrillation in children in cardiac arrest | ||||
| Termination of VF/pVT (important) |
265 (2 non-randomised studies) |
Very low | RR 0.63 (0.14 to 2.84) |
179 fewer per 1,000(from 415 fewer to 888 more) |
| ROSC (critical) |
266 (4 non-randomised studies) |
Very low | RR 1.06 (0.95 to 1.18) |
51 more per 1,000(from 42 fewer to 152 more) |
| Survival to Hospital Discharge (critical) | 225 (2 non-randomised studies) |
Very low | RR 1.06 (0.80 to 1.40) |
29 more per 1,000(from 96 fewer to 192 more) |
| Defibrillation dose > 2.5 J/kg (I) compared to defibrillation dose approximating 2 J/kg (C) for defibrillation in children in cardiac arrest | ||||
| Termination of VF/pVT (important) |
265 (2 non-randomised studies) |
Very low | RR 0.96 (0.82 to 1.13) |
22 fewer per 1,000(from 99 fewer to 77 more) |
| ROSC (critical) |
596 (6 non-randomised studies) |
Very low | RR 0.95 (0.77 to 1.17) |
29 fewer per 1,000(from 133 fewer to 98 more) |
| Survival to Hospital Discharge (critical) | 225 (2 non-randomised studies) |
Very low | RR 1.20 (0.38 to 3.77) |
82 more per 1,000(from 253 fewer to 1,000 more) |
ARD: absolute risk difference; C: comparator; CI: confidence interval; GRADE: Grading of Recommendations, Assessment, Development, and Evaluation
I: intervention; RCT: randomised controlled trial; RR: risk ratio; ROSC: return of spontaneous circulation; VF: ventricular fibrillation; pVT: pulseless ventricular tachycardia.