Table 2.
Characteristics from bronchoalveolar lavage (BAL) and grade for verified immune checkpoint inhibitor pneumonitis (ICIP).
| BAL characteristics, n (median, n = 476), IQR (median [IQR]) | |
|---|---|
| Time from symptom onset to bronchoscopy (days) | 8.0 [3.0, 20.0] |
| Volume instilled (ml) | 100.0 [80.0, 120.0] |
| Volume returned (ml) | 40.0 [35.0, 50.0] |
| Cell percentage percentages (median [IQR]) | |
| Lymphocyte % | 19.0 [8.7, 37.0] |
| Neutrophil % | 8.0 [3.0, 27.0] |
| Eosinophil % | 0 [0.0, 2.0] |
| Histiocyte % | 45.0 [26.0, 65.0] |
| Other cell % | 3.0 [1.0, 9.0] |
| Positive microbiologic data, N (%) | |
| Viral panel | 40 (8) |
| Bacterial culture | 83 (17) |
| Fungal culture | 30 (6) |
| Acid-fast stain^ | 13 (3) |
| Grading of pneumonitis* | |
| Initial grade | |
| 2 | 64 (26) |
| 3 | 173 (72) |
| 4 | 2 (1) |
| Maximum grade | |
| 2 | 36 (15) |
| 3 | 180 (75) |
| 4 | 22 (9) |
| 5 | 1 (4) |
BAL, bronchoalveolar lavage; IQR, interquartile range. ^Includes Mycobacterium abscessus, Mycobacterium avium, Mycobacterium gordonae, Mycobacterium intracellulare. *Grading of pneumonitis as outlined by the Common Terminology Criteria for Adverse Events v5.0.