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. 2025 May 8;99(6):e00248-25. doi: 10.1128/jvi.00248-25

Fig 3.

Line and scatterplots depict weight gain or viral RNA kinetics in PD-1 knockout mice. PD1 mice maintain higher N-gene copies compared to wild-type, with significant difference at day 100, indicating delayed viral resolution.

PD-1 knockout does not impact host health or LDV viremia. (A) Trajectory of weight gain in LDV-infected (brown, n = 6) vs uninfected (gray, n = 7) PD-1 knockout mice. Data were compiled from two independent experiments. Non-significance was determined by unpaired t-test at 100 dpi. (B) Trajectory of LDV viremia in wild-type (black, n = 8) vs PD-1 knockout mice (n = 12). (C) Same data as panel B, with statistical significance determined by unpaired t-test.