Table 3.
Significant clusters presenting different abnormal activations between schizophrenia and bipolar disorder compared to healthy controls.
| Cluster | Side |
Label (Nearest Gray Matter within 5 mm) |
BA |
Peaks (MNI) |
P |
Z |
||
|---|---|---|---|---|---|---|---|---|
| x | y | z | ||||||
| GREATER HYPERACTIVATION IN SCHIZOPHRENIA (SCZ > HC) – (BD > HC) | ||||||||
| 1 | L | Sub-lobar, Claustrum | −34 | −8 | −12 | 0.006 | 2.543 | |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus, Hippocampus | −32 | −12 | −16 | 0.007 | 2.484 | |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus, Hippocampus | −36 | −10 | −16 | 0.009 | 2.366 | |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus, Hippocampus | −34 | −12 | −22 | 0.011 | 2.308 | |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus, Amygdala | −31.1 | −5.3 | −16.2 | 0.014 | 2.197 | |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus, Hippocampus | −28 | −12 | −27 | 0.015 | 2.183 | |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus, Amygdala | −26 | −12 | −21 | 0.015 | 2.170 | |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus, Amygdala | −22 | −7 | −18 | 0.016 | 2.144 | |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus, Amygdala | −29.5 | −1.5 | −20 | 0.018 | 2.108 | |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus, Amygdala | −28 | −4.7 | −24 | 0.025 | 1.969 | |
| 1 | L | Temporal Lobe, Superior Temporal Gyrus | 38 | −33 | 2 | −19 | 0.038 | 1.780 |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus, Amygdala | −31.3 | −2.1 | −27.6 | 0.025 | 1.969 | |
| 2 | R | Limbic Lobe, Uncus, Amygdala | 32.5 | −6.6 | −28.5 | 0.025 | 1.969 | |
| 2 | R | Limbic Lobe, Uncus, Amygdala | 26.8 | −2.8 | −28.4 | 0.025 | 1.969 | |
| 2 | R | Limbic Lobe, Uncus | 28 | 30 | 4 | −26 | 0.023 | 1.995 |
| 2 | R | Limbic Lobe, Uncus | 28 | 36.6 | −1 | −31.3 | 0.025 | 1.969 |
| 2 | R | Limbic Lobe, Parahippocampal Gyrus, Amygdala | 26.7 | −1.3 | −23 | 0.042 | 1.734 | |
| 3 | L | Temporal Lobe, Fusiform Gyrus | 20 | −38.9 | −37 | −18.9 | 0.024 | 1.986 |
| 3 | L | Limbic Lobe, Parahippocampal Gyrus | 36 | −35.3 | −33 | −20 | 0.040 | 1.757 |
| 3 | L | Temporal Lobe, Fusiform Gyrus | 36 | −43 | −36 | −25 | 0.046 | 1.690 |
| GREATER HYPOACTIVATION IN SCHIZOPHRENIA (SCZ < HC) – (BD < HC) | ||||||||
| 1 | L | Limbic Lobe, Parahippocampal Gyrus | 28 | −22 | −22 | −24 | 0.024 | 1.986 |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus | 35 | −20 | −26 | −26 | 0.025 | 1.960 |
| 1 | L | Limbic Lobe, Parahippocampal Gyrus | 35 | −26 | −22 | −25 | 0.034 | 1.832 |
| 2 | L | Brainstem, Midbrain, Substantia Nigra | −8 | −22 | −14 | 0.026 | 1.943 | |
| 2 | L | Brainstem, Midbrain, Red Nucleus | −8 | −22 | −10 | 0.03 | 1.881 | |
| GREATER HYPOACTIVATION IN BIPOLAR DISORDER (BD < HC) – (SCZ < HC) | ||||||||
| 1 | R | Frontal Lobe, Precentral Gyrus | 6 | 38.7 | 10.2 | 28 | 0.007 | 2.484 |
| 1 | R | Frontal Lobe, Middle Frontal Gyrus | 9 | 46 | 18 | 26 | 0.025 | 1.960 |
| 1 | R | Frontal Lobe, Inferior Frontal Gyrus | 9 | 46 | 18 | 22 | 0.009 | 2.387 |
| 1 | R | Frontal Lobe, Precentral Gyrus | 9 | 45.3 | 12.9 | 29.3 | 0.01 | 2.326 |
| 1 | R | No Gray Matter found | 34.3 | 12 | 35 | 0.011 | 2.290 | |
| 1 | R | Frontal Lobe, Inferior Frontal Gyrus | 9 | 48 | 16 | 18 | 0.029 | 1.896 |
| 1 | R | Frontal Lobe, Precentral Gyrus | 9 | 44 | 24 | 35 | 0.031 | 1.866 |
| 1 | R | Frontal Lobe, Precentral Gyrus | 9 | 39.2 | 13.5 | 34.2 | 0.007 | 2.484 |
| 1 | R | Frontal Lobe, Inferior Frontal Gyrus | 9 | 50 | 10 | 20 | 0.046 | 1.690 |
| 1 | R | No Gray Matter found | 28.8 | 7.8 | 35 | 0.048 | 1.670 | |