Table 2.
Characteristics of Patients and Univariate Analysis of Factors Associated with Invasive Fungal Infection during Admissions for Intensive Chemotherapy and Hematopoietic Stem Cell Transplant
| IFI | Univariate analysis | |||||
|---|---|---|---|---|---|---|
| Total n=132 (%) |
Yes n=17 (%) |
No n=115 (%) |
Odds ratio | 95% CI | p value | |
| HSCT | ||||||
| Yes | 46 (34.8) | 3 (6.5) | 43 (93.5) | 0.36 | 0.01 – 1.32 | 0.111 |
| No | 86 (65.2) | 14 (16.3) | 72 (83.7) | |||
| Types of HSCT (n=46) | ||||||
| Allogeneic/ | 18 (39.1) | 2 (11.1) | 16 (88.9) | 3.38 | 0.28 – 40.25 | 0.552 |
| Haploidentical | ||||||
| Autologous | 28 (60.9) | 1 (3.6) | 27 (96.4) | |||
| PICC | ||||||
| Yes | 112 (84.8) | 17 (15.2) | 95 (84.8) | 0.85 | 0.78 – 0.92 | 0.074 |
| No | 20 (15.2) | 0 (0.0) | 20 (100.0) | |||
| Antifungal prophylaxis | ||||||
| Yes | 125 (94.7) | 14 (11.2) | 111 (88.8) | 0.17 | 0.03 – 0.83 | 0.045* |
| No | 7 (5.3) | 3 (42.9) | 4 (57.1) | |||
| Neutropenia >7 days | ||||||
| Yes | 88 (66.7) | 17 (19.3) | 71 (80.7) | - | - | 0.002 |
| No | 44 (33.3) | 0 (0.0) | 44 (100.0) | |||
| Bacterial infection | ||||||
| Yes | 54 (40.9) | 12 (22.2) | 42 (77.8) | 4.17 | 1.37 – 12.66 | 0.009* |
| No | 78 (59.1) | 5 (6.4) | 73 (93.6) | |||
Abbreviations: IFI, invasive fungal infection; CI, confidence internal; HSCT, haematopoietic stem cell transplantation; PICC, peripherally inserted central catheter * P <0.05 is statistically significant