Table 1.

Ferroptosis inducer form.

Medicine	Mechanism	Experimental model	Related genes	Cite
Withaferin	Inhibit GPX4 activity, degrade heme and increase iron content.	Human neuroblastoma cells IMR-32 and SK-N-SH	CPX4	Song Q et al. (50)
FINO2	Inhibiting GPX4 and ferric oxide	Human fibrosarcoma cell HT-1080, human immortalized skin tissue cell BJeLR.	CPX4	Faust D et al. (51)
Temozolomide (TMZ)	Decreased the expression of Nrf2 and HO-1, and up-regulated DMT1.	Human glioblastoma cell line TG905	DMT1, SQLE, GPX4	Song Q et al. (50)
Iron-based nanomaterials	Inhibition of tumor growth by Fenton reaction	MMTV-PyMT (mouse breast tumor virus-T antigen in polyoma) breast cancer cells	TfR1、FPN1、HO-1	Chen M et al. (54), Geppert M et al. (239)
Sorafenib	Inhibition system Xc enhances intracellular iron content.	Hepatocellular carcinoma (HCC) tissue	SLC711, STAT3,MCL1	Dhiman P et al. (55)
Erastin	Inhibition of System Xc-, interference with cystine uptake, decrease of GSH and increase of lipid peroxidation level.	Human cervical cancer cell Hela, human ovarian cancer cell COV362	p53	Xiong Y et al. (59), Wu H et al. (60)
Buthionine sulfoxide imine (BSO)	Inhibit the activity of glutamyl-cysteine ligase and block the production of GSH.	Neuroblastoma cell line	p53,GPX4,ATM	Cunningham A et al. (244), Yoshioka et al. (63), Chen X et al. (64)
RSL3	Cysteine binding to GPX4 active site inhibits GPX4 activity.	Human fibrosarcoma cell HT-1080 and nude mice transplanted tumor model	GPX4,SLC711,SLC3A2	Tang R et al. (52)
Statins	Inhibit GPX4	Triple negative breast cancer (TNBC) cells	GPX4	MILLÁN M et al. (68)
FIN56	Inhibit GPX4;; Combined with squalene synthase (SQS), CoQ is consumed.	Four kinds of engineered BJ cell lines, 143B cells (osteosarcoma), Calu-1 cells (lung adenocarcinoma) and HT-1080 cells (fibrosarcoma).	SLC7A11 GPX4 FSP1	Deepa S et al. (67), Costa I et al. (245)