Table 2.
Ferroptosis inhibitor form.
| Medicine | Mechanism | Experimental model | Related genes | Cite |
|---|---|---|---|---|
| Iron chelating agent | It can selectively target Fe2+ in cells and prevent ROS produced by Fenton reaction. | Middle cerebral artery occlusion (MCAO) model in rats | GPX4, ACSL4, |
Kosyakovsky J et al. (246), MILLÁN M et al. (68) |
| YL 939 | Regulate ferritin expression and ferritin phagocytosis, and reduce the iron level in intracellular LIP. | Acetaminophen-induced liver injury model | PHB2 | Wang Y et al. (74) |
| Ferristatin II | Promote the degradation of TfR1 and interfere with Tf-mediated iron delivery. | Mouse TBI model | TfR1, 、 Tf |
Wang Y et al. (74) |
| 9a | Destroy the interaction between NCOA4-FTH1 protein and protein to reduce the amount of bioavailable intracellular ferrous iron. | Rat model of ischemic stroke | NCOA4-FTH1 | Fang et al. (72) |
| Fer-1 | Quickly react with peroxy free radicals in cells to block the amplification of chain reaction in lipid peroxidation. | Cell models of Huntington’s disease (HD), periventricular leukomalacia (PVL) and renal dysfunction | SLC711,GPX4 | Li Z et al. (247) |
| Lip-1 | ROS produced by lipid peroxidation | Mouse melanoma cells | EGRI,SLC711,GPX4 | Bao C et al. (248) |
| β-MErcaptoethanol (β-me) | Increase GPX4 expression. | Mouse lymphoma L1210 cells | Transcription factors TFAP2c, HSP90, | Fang Y et al. (79), Gu Y et al. (80) |
| Novel diphenyl butene inhibitor compound 3f | Increase FSP1 protein level | Rat model of ischemic stroke | FSP1 | Fang et al. (79) |