Table 3.

Time-varying Cox regression model for all-cause mortality.

Variable	Model 1		Model 2		Model 3
	HR (95%CI)	p-value	HR (95%CI)	p-value	HR (95%CI)	p-value
90-day mortality
RAR (per unit)	1.11 (1.04 ~ 1.19)	0.001	1.10 (1.03 ~ 1.17)	0.003	1.14 (1.05 ~ 1.22)	0.001
RAR (quartiles)
Q1 (RAR < 3.22)	1 (ref)		1 (ref)		1 (ref)
Q2 (3.22 ≤ RAR < 3.66)	1.61 (0.77 ~ 3.38)	0.206	1.63 (0.78 ~ 3.41)	0.195	1.77 (0.84 ~ 3.75)	0.132
Q3 (3.66 ≤ RAR < 4.39)	1.74 (0.87 ~ 3.48)	0.115	1.75 (0.88 ~ 3.50)	0.113	1.79 (0.89 ~ 3.60)	0.104
Q4 (4.39 ≤ RAR)	3.18 (1.66 ~ 6.09)	<0.001	3.17 (1.65 ~ 6.06)	<0.001	3.65 (1.89 ~ 7.06)	<0.001
P for trend		<0.001		<0.001		<0.001
365-day mortality
RAR (per unit)	1.14 (1.10 ~ 1.17)	<0.001	1.11 (1.08 ~ 1.15)	<0.001	1.07 (1.02 ~ 1.13)	0.005
RAR (quartiles)
Q1 (RAR < 3.22)	1 (ref)		1 (ref)		1 (ref)
Q2 (3.22 ≤ RAR < 3.66)	1.13 (0.82 ~ 1.55)	0.459	1.05 (0.76 ~ 1.44)	0.764	1.02 (0.74 ~ 1.40)	0.911
Q3 (3.66 ≤ RAR < 4.39)	1.85 (1.38 ~ 2.47)	<0.001	1.66 (1.24 ~ 2.23)	0.001	1.35 (1.00 ~ 1.82)	0.05
Q4 (4.39 ≤ RAR)	2.62 (1.99 ~ 3.46)	<0.001	2.46 (1.87 ~ 3.24)	<0.001	1.67 (1.24 ~ 2.25)	0.001
P for trend		<0.001		<0.001		<0.001

Model 1: unadjusted.

Model 2: adjusted for age, gender, race.

Model 3: adjusted for Model 2 plus SOFA, LODS, sepsis, BUN, Potassium, Glucose, Vasoactive drug, Statin, Mannitol, CRRT, Cerebral surgery, Length of stay in hospital.

RAR, red blood cell distribution width to albumin ratio; SOFA, sequential organ failure assessment; LODS, Logistic Organ Dysfunction System; BUN, blood urea nitrogen; CRRT, continuous renal replacement therapy.