2.

(a) RMSD values for Alpfafoldv2 and generic homology modeling performed using SwissModel and the cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex. On the right, showing the hybrid homology modeling structure for OR51E2, modeled using the Olfr78 structure from AFv2, hybrid structures from mouse and human ORs, and AFv3 structures with an AFv3-hybrid comparison. Pruned pairs are the subset of atom pairs retained after removing mismatched/unsuitable atoms, ensuring more accurate RMSD calculation (e.g., RMSD between 219 pruned atom pairs is 1.019 Å and across all 302 pairs: 2.238). (b) Ramachandran plots for the two protein models in focus, OR51G2. AFv2 models show outliers­(in red), while the hybrid model has its residue data within the constraints.