Table 6.
Incidence of nonneoplastic lesions exhibiting significant change in mice
| Effect | Vehicle Control | 2.5 mg/kg | 12.5 mg/kg | 25 mg/kg | |
|---|---|---|---|---|---|
| Male | |||||
| Splenic Hematopoietic Cell Proliferation | ↑ | 14/49 (2.6) | 16/50 (2.7) | 25/49* (2.8) | 29/48** (2.5) |
| Female | |||||
| Splenic Hematopoietic Cell Proliferation | ↑ | 23/47 (2.7) | 21/47 (2.5) | 31/49 (1.1) | 40/50** (1.0) |
| Nose Inflammation | ↑ | 0/50 | 3/50 (2.0) | 7/50* (2.0) | 11/50** (1.9) |
*
Significantly different (P≤0.05) from vehicle control by the Poly−3 test
**
(P≤0.01)
a
Average severity grade of lesions in affected animals: 1=minimal, 2=mild, 3=moderate, 4=marked