Table 2.
Univariate and multivariate Cox proportional hazards analyses of the associations of TLCκ, TLCλ, κ/λ, and ΣTLC with all-cause mortality in centenarians
| Number | Univariate analysis | Multivariate-adjusted analysis | |||
|---|---|---|---|---|---|
| HR | P | HR | P | ||
| TLCκ per 1 g/L | 906 | 1.127(1.055,1.205) | < 0.001 | 1.174(1.024,1.346) | 0.021 |
| Group by Interquartile Value | |||||
| Q1 [1.72,3.54) | 226 | 1 | 1 | ||
| Q2 [3.54,4.13) | 225 | 0.952(0.783,1.157) | 0.619 | 0.939(0.759,1.161) | 0.560 |
| Q3 [4.13,4.78) | 223 | 1.264(1.042,1.532) | 0.017 | 1.329(1.051,1.679) | 0.017 |
| Q4 [4.78,7.64] | 232 | 1.358(1.122,1.644) | 0.002 | 1.434(1.061,1.939) | 0.019 |
| P for trend | < 0.001 | 0.003 | |||
| Group by P50 Value | |||||
| Q1-Q2 [1.72,4.13) | 451 | 1 | 1 | ||
| Q3-Q4 [4.13,7.64] | 455 | 1.343(1.172,1.539) | < 0.001 | 1.411(1.175,1.693) | < 0.001 |
| E-values | 1.754(1.476, Inf) | 1.854(1.481, Inf) | |||
| TLCλ per 1 g/L | 906 | 1.174(1.043,1.322) | 0.008 | 1.088(0.882,1.341) | 0.432 |
| Group by Interquartile Value | |||||
| Q1 [0.93,1.78) | 227 | 1 | 1 | ||
| Q2 [1.78,2.09) | 222 | 0.964(0.794,1.171) | 0.713 | 1.007(0.817,1.241) | 0.946 |
| Q3 [2.09,2.49) | 228 | 1.147(0.947,1.389) | 0.162 | 1.197(0.954,1.502) | 0.121 |
| Q4 [2.49,4.71] | 229 | 1.337(1.105,1.618) | 0.003 | 1.351(1.013,1.802) | 0.041 |
| P for trend | < 0.001 | 0.022 | |||
| Group by P50 Value | |||||
| Q1-Q2 [0.93,2.09) | 449 | 1 | 1 | ||
| Q3-Q4 [2.09,4.71] | 457 | 1.258(1.098,1.441) | < 0.001 | 1.227(1.028,1.465) | 0.023 |
| E-values | 1.622(1.334, Inf) | 1.571(1.160, Inf) | |||
| κ/λ per 1 unit | 906 | 1.067(0.894,1.272) | 0.473 | 1.050(0.873,1.263) | 0.607 |
| Group by Interquartile Value | |||||
| Q1 [1,1.75) | 227 | 1 | 1 | ||
| Q2 [1.75,1.97) | 226 | 1.067(0.881,1.293) | 0.505 | 1.103(0.907,1.340) | 0.325 |
| Q3 [1.97,2.19) | 226 | 1.008(0.831,1.223) | 0.932 | 1.023(0.841,1.244) | 0.823 |
| Q4 [2.19,3.98] | 227 | 1.087(0.898,1.316) | 0.392 | 1.082(0.886,1.320) | 0.441 |
| P for trend | 0.530 | 0.623 | |||
| Group by P50 Value | |||||
| Q1-Q2 [1,1.97) | 453 | 1 | 1 | ||
| Q3-Q4 [1.97,3.98] | 453 | 1.014(0.885,1.161) | 0.846 | 1.000(0.870,1.149) | 0.999 |
| E-values | 1.109(1.000, Inf) | 1.100(Inf, 1.000) | |||
| Σ TLC per 1 g/L | 906 | 1.084(1.036,1.135) | < 0.001 | 1.146(1.027,1.279) | 0.015 |
| Group by Interquartile Value | |||||
| Q1 [2.74,5.4) | 227 | 1 | 1 | ||
| Q2 [5.4,6.24) | 223 | 1.099(0.905,1.335) | 0.341 | 1.172(0.943,1.455) | 0.152 |
| Q3 [6.24,7.2) | 229 | 1.119(0.922,1.358) | 0.255 | 1.278(0.996,1.640) | 0.054 |
| Q4 [7.2,12.3] | 227 | 1.516(1.251,1.837) | < 0.001 | 1.891(1.347,2.654) | < 0.001 |
| P for trend | < 0.001 | 0.001 | |||
| Group by P75 Value | |||||
| Q1-Q3 [2.74,7.2) | 679 | 1 | 1 | ||
| Q4 [7.2,12.3] | 227 | 1.416(1.213,1.652) | < 0.001 | 1.468(1.172,1.839) | < 0.001 |
| E-values | 1.861(1.548, Inf) | 1.934(1.476, Inf) | |||
Multivariate-adjusted analysis adjusted for age, gender, ethnicity, marital status, body mass index, education, smoking status, alcohol status, diabetes mellitus, hypertension, coronary heart disease, estimated glomerular filtration rate (eGFR), serum IgM, IgG, IgA, IgE, C3, C4. When taking TLCκ or TLCλ as the predictor, TLCλ or TLCκ was also included in the model.