Table 2.
Echocardiographic and Computed tomography parameters for AV characterization, by sex.
| Overall | Women | Men | P value | |
|---|---|---|---|---|
| N = 651 | N = 356 | N = 295 | ||
| LVEF, % | 60 [52, 65] | 65 [55, 68] | 60 [50, 65] | <0.001 |
| EF>50%, n | 521 (80) | 300 (84.3) | 221 (74.9) | 0.004 |
| AVA, cm2 | 0.7 [0.6, 0.8] | 0.7 [0.5, 0.8] | 0.7 [0.6, 0.8] | 0.001 |
| AVAi, | 0.4 [0.3, 0.5] | 0.4 [0.3, 0.5] | 0.4 [0.3, 0.4] | 0.216 |
| AV mean PG, mmHg | 40 [29.4, 47] | 40.4 [30, 48] | 37.7 [29, 45.2] | 0.175 |
| AV max PG, mmHg | 64 [50.2, 81.3] | 66.9 [51, 82] | 63.3 [50, 80] | 0.248 |
| AV max velocity, cm/s | 4 ± 0.7 | 4.1 ± 0.7 | 3.9 ± 0.7 | 0.069 |
| LVOT diameter | 2 [1.9, 2.1] | 1.9 [1.8, 2] | 2 [2, 2.1] | <0.001 |
| Stroke volume, mL | 62.5 [51.3, 74.3] | 61 [49, 73] | 65.6 [54.4, 75.9] | 0.008 |
| Stroke volume indexed, mL/m2 | 31.6 [22.2, 40.4] | 31.9 [22.3, 41.6] | 31.3 [22, 38.9] | 0.284 |
| IVS diameter | 1.2 [1, 1.3] | 1.1 [1, 1.3] | 1.2 [1.1, 1.3] | 0.008 |
| AV Morphology | ||||
| Tricuspid | 605 (92.9) | 337 (94.7) | 268 (90.8) | 0.082 |
| AV Hemodynamics | ||||
| High-gradient AS | 337 (51.8) | 195 (54.8) | 142 (48.1) | 0.108 |
| Fibrotic-calcific volume, mm3/cm2 | 258 [188, 340] | 230 [166, 311] | 293 [217, 382] | <0.001 |
| Fibrotic volume, mm3/cm2 | 126 [82, 193] | 127 [79, 204] | 125 [87, 184] | 0.805 |
| Calcific volume, mm3/cm2 | 111 [67, 177] | 85[49, 132] | 149 [101, 217] | <0.001 |
| Fibro-calcific ratio | 1.1 [0.6, 2.1] | 1.5 [0.8, 2.8] | 0.8 [0.5, 1.5] | <0.001 |
| AV Annulus area, cm2 | 4.3 (1) | 3.8 (0.8) | 4.9 (1) | <0.001 |
Values are presented as n (%); mean ± SD; median [IQR].
AS, aortic stenosis; AV, aortic valve; AVA, aortic valve area; EF, ejection Fraction; IVS, interventricular septum; LVOT, left ventricle, outflow tract; PG, pressure gradient.