Table 4.
Echocardiography and advanced cardiac computed tomography characteristics, stratified by AS hemodynamic phenotype.
| Low-gradient N = 314 |
High-gradient N = 337 |
P value | |
|---|---|---|---|
| Ejection Fraction, % | 60 [45, 65] | 65 [55, 65] | <0.001 |
| EF>50% | 222 (70.7) | 299 (88.7) | <0.001 |
| AVA, cm2 | 0.8 [0.6, 0.9] | 0.7 [0.5, 0.8] | <0.001 |
| AVAi, | 0.4 [0.4, 0.5] | 0.4 [0.3, 0.4] | <0.001 |
| AV mean PG, mmHg | 29 [24, 33] | 47 [43, 54.9] | <0.001 |
| AV max PG, mmHg | 50 [42, 57.8] | 80 [71, 92] | <0.001 |
| AV max velocity, m/s | 3.4 ± 0.4 | 4.5 ± 0.6 | <0.001 |
| LVOT diameter, mm | 2 [1.8, 2.1] | 2 [1.9, 2] | 0.553 |
| Stroke Volume, mL | 58 [47.3, 69] | 67 [57.5, 80] | <0.001 |
| Stroke Volume indexed, mL/m2 | 30.2 [22, 36.8] | 34.0 [22.3, 42.1] | 0.005 |
| IVS diameter, mm | 1.1 [1, 1.3] | 1.2 [1.1, 1.4] | <0.001 |
| Valve Morphology | |||
| Tricuspid | 295 (93.9) | 310 (92) | 0.411 |
| Bicuspid | 19 (6.1) | 27 (8) | |
| TAVR | 225 (71.7) | 268 (79.5) | 0.025 |
| Death | 73 (23.2) | 53 (15.7) | 0.02 |
| Advanced CT AV characterization | |||
| Fibro-calcific volume, mm/cm2 | 218.9 [171, 295] | 294.9 [222.1, 388.8] | <0.001 |
| Fibrotic volume, mm/cm2 | 117.4 [80.2, 189.4] | 136.6 [84, 197] | 0.099 |
| Calcific volume, mm/cm2 | 87.6 [52.9, 124.2] | 147.7 [86.5, 211.7] | <0.001 |
| Fibro-calcific ratio | 1.4 [0.8, 2.6] | 0.9 [0.5, 1.6] | <0.001 |
| Annulus area, cm2 | 4.3 [3.6, 5.1] | 4.1 [3.5, 4.8] | 0.044 |
Values are presented as n (%); mean ± SD; median [IQR].
AV, aortic valve; AVA, aortic valve area; CT, computed tomography; LVOT, left ventricular outflow tract; PG, pressure gradient; TAVR, transcatheter aortic valve replacement.