Table 3.
Final popPK/PD Model Parameters Estimation of Remimazolam
| Parameters | Final Model | Bootstrap (N=1000) | ||
|---|---|---|---|---|
| Estimates | RSE (%) | Median | 95% CI | |
| Typical value | ||||
| CL (L/min) | 1.33 | 4 | 1.34 | 1.20–1.45 |
| V1 (L) | 6.35 | 17 | 6.8 | 3.74–8.95 |
| V2 (L) | 28.2 | 12 | 28.7 | 20.44–35.89 |
| Q2 (L/min) | 0.293 | 16 | 0.298 | 0.19–0.39 |
| Q3 (L/min) | 1.09 | 17 | 1.09 | 0.46–1.71 |
| V3 (L) | 10.9 | 7 | 11.14 | 8.86–12.87 |
 |
80.7 | 4 | 74.93 | 61.30–100 |
 (ng/mL) |
809 | 7 | 744 | 561–1056 |
| BIS_ baseline | 91.9 | 1 | 91.5 | 88.9–94.7 |
 (min−1) |
0.13 | 7 | 0.13 | 0.11–0.15 |
| Hill coefficient | 1.65 | 16 | 1.74 | 1.08–2.22 |
| Inter-individual variation (IIV) | ||||
| IIV_CL (%) | 16 | 18 | 15 | 7.6–21.2 |
| IIV_V1 (%) | 71.1 | 19 | 64.7 | 43.9–90.5 |
| IIV_Q2 (%) | 61.5 | 18 | 60.9 | 32.3–80.7 |
| IIV_V2 (%) | 40.6 | 24 | 40.2 | 14–55.7 |
| IIV_Q3 (%) | 55.8 | 30 | 55 | 0–83.6 |
IIV_ (%) |
15 | 31 | 15 | 0–23 |
IIV_ (%) |
12.2 | 81 | 15.4 | 0–26 |
| IIV_HILL (%) | 47.2 | 24 | 45.3 | 26.2–61 |
| Residual unexplained variability (RUV) | ||||
| prop RUV (%) | 0.161 | 1 | 0.162 | 0.133–0.184 |
| prop RUV (%) | 0.09 | 0 | 0.089 | 0.071–0.11 |
Abbreviations: CL, clearance; V1, central volume; V2, peripheral volume; V3, peripheral volume; Q2, intercompartmental clearance; Q3, intercompartmental clearance; Ktr, transit rate constant; V5, central volume for CNS 7054; 
, elimination rate constant; RSE, residual standard error; CI, confidence intervals.