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. 2025 May 26;27:2473–2480. doi: 10.1016/j.csbj.2025.05.029

Table 1.

Comparison Results (Mean Scores in %).

Model Pang et al.
BioSNAP
AdverseDDI
F1 ACC AUROC F1 ACC AUROC F1 ACC AUROC
RFC 79.94 81.19 89.60 74.80 74.34 82.57 77.17 75.42 83.60
DeepDDI 81.43 90.44 92.18 88.60 89.23 94.74 87.26 87.45 94.34
DeepDDS 89.05 88.65 94.86 87.55 87.93 95.21 82.45 85.34 93.07
Deepconv 97.19 97.30 98.61 97.70 97.70 99.14 88.65 88.74 95.21
LSTM 96.35 96.14 98.49 97.75 97.72 98.78 88.41 88.23 94.30
GAT 95.87 95.39 97.30 91.19 91.52 96.82 86.14 85.92 93.62
AMDE 97.33 96.68 98.90 97.37 97.38 99.19 86.57 86.33 93.54
HTCL-DDI 96.33 96.34 95.99 - - - 85.07 85.27 92.14
DSN-DDI 96.90 96.80 98.28 93.72 93.55 97.89 83.76 84.13 92.62
MFE-DDI 97.91 97.87 99.18 98.20 98.23 99.22 89.52 89.38 95.62

Due to equipment memory limitation, we were unable to run HTCL-DDI on BioSNAP dataset.