Table 3. Univariate and multivariate HRs and 95% CIs for major surgery in ulcerative colitis and Crohn’s disease, by time of diagnosis.
| Univariate analysis | Multivariate analysis* | |||
|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | |
| Ulcerative colitis | ||||
| 1987–1994 | 1.0 | 1.0 | ||
| 1995–2002 | 0.56 | 0.54 to 0.59 | 0.59 | 0.56 to 0.62 |
| 2003–2010 | 0.42 | 0.40 to 0.44 | 0.45 | 0.42 to 0.47 |
| 2011–2017 | 0.33 | 0.31 to 0.36 | 0.39 | 0.36 to 0.42 |
| p<0.001 | p<0.001 | |||
| Age at diagnosis | ||||
| <20 | 1.0 | 1.0 | ||
| 20–40 | 0.81 | 0.76 to 0.86 | 0.90 | 0.84 to 0.96 |
| 40–60 | 0.74 | 0.69 to 0.79 | 0.85 | 0.79 to 0.90 |
| >60 | 0.82 | 0.77 to 0.89 | 1.01 | 0.94 to 1.09 |
| p<0.001 | p<0.001 | |||
| Sex | ||||
| Female | 1.0 | 1.0 | ||
| Male | 0.97 | 0.95 to 1.0 | 0.95 | 0.91 to 0.99 |
| Nationality | ||||
| Sweden | 1.0 | 1.0 | ||
| Norway | 0.95 | 0.92 to 0.99 | 0.90 | 0.85 to 0.95 |
| Extent of disease | ||||
| Proctitis | 1.0 | 1.0 | ||
| Left-sided colitis | 0.46 | 0.42 to 0.51 | 0.50 | 0.45 to 0.56 |
| Extensive | 2.36 | 2.21 to 2.51 | 2.33 | 2.18 to 2.48 |
| Not defined | 1.73 | 1.61 to 1.87 | 1.53 | 1.42 to 1.66 |
| Crohn’s disease | ||||
| 1987–1994 | 1.0 | 1.0 | ||
| 1995–2002 | 0.63 | 0.61 to 0.66 | 0.81 | 0.77 to 0.85 |
| 2003–2010 | 0.46 | 0.43 to 0.48 | 0.69 | 0.65 to 0.72 |
| 2011–2017 | 0.39 | 0.37 to 0.42 | 0.69 | 0.65 to 0.75 |
| p<0.001 | p<0.001 | |||
| Age at diagnosis | ||||
| <20 | 1.0 | 1.0 | ||
| 20–40 | 1.06 | 1.01 to 1.12 | 1.00 | 0.94 to 1.06 |
| 40–60 | 0.95 | 0.90 to 1.01 | 0.92 | 0.86 to 0.97 |
| >60 | 0.82 | 0.76 to 0.88 | 0.95 | 0.89 to 1.02 |
| p<0.001 | p<0.001 | |||
| Sex | ||||
| Female | 1.0 | 1.0 | ||
| Male | 0.99 | 0.96 to 1.02 | 0.96 | 0.93 to 1.00 |
| Nationality | ||||
| Sweden | 1.0 | 1.0 | ||
| Norway | 0.97 | 0.94 to 1.01 | 0.91 | 0.86 to 0.96 |
| Location of disease | ||||
| Terminal ileum | 1.0 | 1.0 | ||
| Colon | 0.69 | 0.64 to 0.73 | 0.74 | 0.69 to 0.79 |
| Ileocolonic | 1.63 | 1.55 to 1.71 | 1.29 | 1.23 to 1.36 |
| Not defined | 0.38 | 0.34 to 0.42 | 0.43 | 0.39 to 0.48 |
| Behaviour of disease | ||||
| Non-stricturing, non-penetrating | 1.0 | 1.0 | ||
| Stricturing | 4.19 | 4.02 to 4.38 | 3.43 | 3.28 to 3.59 |
| Penetrating | 3.39 | 3.19 to 3.61 | 2.81 | 2.62 to 3.01 |
| Both stricturing and penetrating | 6.50 | 6.09 to 6.94 | 4.70 | 4.34 to 5.03 |
| Perianal disease | ||||
| No | 1.0 | 1.0 | ||
| Yes | 1.92 | 1.84 to 2.00 | 0.99 | 0.94 to 1.04 |
HRs for major surgery during follow-up in a cohort of 128 834 patients with ulcerative colitis and Crohn’s disease.
*
Adjusted for year of diagnosis (groups 1987–1994, 1995–2002, 2003–2010 and 2011–2017), age, sex, nationality, extent of disease (UC), behaviour of disease (CD) and perianal disease (CD).
CD, Crohn’s disease; UC, ulcerative colitis.