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. 2025 Jun 18;15(6):e094046. doi: 10.1136/bmjopen-2024-094046

Table 4. Estimation of direct and indirect effects of depression on dry eye disease through poor sleep quality: a mediation analysis.

Pathway Coef. 95% CI P value OR 95% CI
Direct effect:Depression → DED 0.12 0.02, 0.23 0.021 1.66 1.06, 2.58
Indirect effect:Depression → poor sleep quality → DED 0.06 0.04, 0.09 <0.001 1.32 1.18, 1.49
Total effect 0.19 0.04, 0.09 <0.001 2.20 1.41, 3.41

DED, dry eye disease.