Table 2.

Performance metrics of the best models for each metabolic subphenotype for each feature set

Prediction task	Feature set	auROC	Sensitivity	Specificity	F1	Precision	Accuracy	Classifier
Muscle IR	Demographics	0.37	0.55	0.56	0.55	0.58	0.56	SVM-RBF
	Demographics + PRS	0.21	0.38	0.26	0.27	0.25	0.29	RF
	Demographics + Lab	0.69	0.67	0.65	0.66	0.68	0.66	LR-L1
	Demographics + Incretins	0.38	0.85	0.34	0.66	0.58	0.59	SVM-RBF
	Demographics + HOMA-B	0.44	0.98	0.02	0.40	0.50	0.53	LR-L1
	Demographics + HOMA-IR	0.77	0.74	0.71	0.73	0.76	0.72	LR-L1
	Demographics + Matsuda	0.83	0.85	0.42	0.71	0.66	0.65	SVM-linear
	Demographics + OGTT_G_Curve_Features	0.90	0.90	0.75	0.83	0.81	0.82	SVM-linear
	Demographics + OGTT_G_ReducedRep	0.95	0.81	0.91	0.85	0.93	0.87	LR-L1
β-cell function	Demographics	0.49	0.69	0.30	0.52	0.60	0.51	SVM-RBF
	Demographics + PRS	0.46	0.77	0.12	0.35	0.42	0.44	LR-L1
	Demographics + Lab	0.50	0.82	0.18	0.59	0.62	0.56	SVM-linear
	Demographics + Incretins	0.72	0.93	0.01	0.54	0.43	0.53	SVM-RBF
	Demographics + HOMA-B	0.48	0.98	0.01	0.52	0.22	0.58	SVM-linear
	Demographics + HOMA-IR	0.57	0.71	0.19	0.55	0.55	0.50	LR-L1
	Demographics + Matsuda	0.44	0.74	0.29	0.61	0.62	0.56	SVM-RBF
	Demographics + OGTT_G_Curve_Features	0.84	0.78	0.72	0.79	0.82	0.75	SVM-linear
	Demographics + OGTT_G_ReducedRep	0.89	0.82	0.73	0.82	0.85	0.78	SVM-linear
Incretin effect	Demographics	0.62	0.51	0.88	0.63	0.81	0.72	LR-L1
	Demographics + PRS	0.53	0.33	0.67	0.37	0.41	0.54	RF
	Demographics + Lab	0.80	0.64	0.78	0.66	0.74	0.71	RF
	Demographics + Incretins	0.68	0.60	0.64	0.54	0.56	0.62	RF
	Demographics + HOMA-B	0.68	0.62	0.61	0.55	0.57	0.61	RF
	Demographics + HOMA-IR	0.75	0.60	0.76	0.63	0.71	0.69	RF
	Demographics + Matsuda	0.48	0.72	0.56	0.63	0.56	0.62	SVM-linear
	Demographics + OGTT_G_Curve_Features	0.90	0.75	0.74	0.71	0.73	0.74	SVM-RBF
	Demographics + OGTT_G_ReducedRep	0.88	0.79	0.72	0.73	0.71	0.75	LR-L1
Hepatic IR	Demographics	0.63	0.71	0.47	0.60	0.57	0.58	LR-L1
	Demographics + PRS	0.45	0.34	0.61	0.33	0.36	0.51	SVM-RBF
	Demographics + Lab	0.78	0.90	0.45	0.74	0.66	0.67	SVM-RBF
	Demographics + Incretins	0.73	0.70	0.60	0.63	0.62	0.64	RF
	Demographics + HOMA-B	0.50	0.52	0.48	0.48	0.50	0.48	SVM-RBF
	Demographics + HOMA-IR	0.88	0.80	0.80	0.78	0.83	0.80	LR-L1
	Demographics + Matsuda	0.90	0.82	0.71	0.76	0.78	0.76	SVM-linear
	Demographics + OGTT_G_Curve_Features	0.84	0.78	0.73	0.76	0.76	0.75	RF
	Demographics + OGTT_G_ReducedRep	0.54	0.73	0.52	0.65	0.64	0.63	SVM-linear