Table 2. Fitting equations for cumulative release time models of TBH–DMN and Gls–TBH-NE–DMN in vitroa.
| Group | Model | Model fitting equation | r |
|---|---|---|---|
| TBH–DMN | Zero-order kinetic |
 = −0.1479 + 07986t
|
r = 0.9847 |
| First-order kinetic |
 = 63 326.1420 × (1 − e−1.1495t) |
r = 0.9630 | |
| Higuchi |
 = 2.4089t1/2 − 1.2646 |
r = 0.8174 | |
| Gls–TBH-NE–DMN | Zero-order kinetic |
 = −0.1265 + 1.6247t
|
r = 0.8024 |
| First-order kinetic |
 = 71.7346 × (1 − e−0.0638t) |
r = 0.9626 | |
| Higuchi |
 = 9.4226t1/2 − 2.6617 |
r = 0.9965 |
a
Terbinafine hydrochloride dissolving microneedles (TBH–DMN), dissolving microneedles of terbinafine hydrochloride nanoemulsion for beta-1,3-glucanase (Gls–TBH-NE–DMN).