Table 3.

Logistic model and diagnostic performances of CSF and blood biomarkers.

Variable	St. coefficient	Variable p	Cut-off	AUC [95% CI]	Optimal SE	Optimal SP	PPV	NPV
CSF
Aβ42	−1.82	<0.001	759.001	0.844 [0.764, 0.923]	0.866	0.667	0.84	0.69
Aβ40	0.52	0.036	10,894.925	0.641 [0.525, 0.758]	0.597	0.697	0.80	0.46
tTau	2.27	<0.001	366.999	0.860 [0.784, 0.936]	0.896	0.727	0.87	0.77
pTau	4.61	<0.001	63.300	0.931 [0.879, 0.983]	0.851	0.939	0.97	0.76
Aβ42/tTau	−2.57	<0.001	1.843	0.935 [0.887, 0.983]	0.910	0.879	0.94	0.83
Aβ42/pTau	−3.88	<0.001	12.997	0.978 [0.954, 1.000]	0.940	0.939	0.97	0.89
Plasma
Aβ42	−1.37	<0.001	30.836	0.781 [0.684, 0.877]	0.881	0.576	0.81	0.68
Aβ40	−0.44	0,072	195.978	0.602 [0.486, 0.717]	0.224	1.000	1.00	0.38
pTau181	3.16	<0.001	2.180	0.869 [0.796, 0.942]	0.791	0.818	0.90	0.64
pTau217	5.37	<0.001	0.327	0.911 [0.853, 0.969]	0.836	0.939	0.97	0.74
Aβ42/40	−0.01	0.947	0.081	0.802 [0.713, 0.892]	0.746	0.818	0.89	0.61
Aβ42/40*	−1.49	<0.001	0.086	0.834 [0.748; 0.920]	0.778	0.818	0.89	0.66
NfL	−0.42	0.065	44.840	0.609 [0.484, 0.734]	0.866	0.424	0.75	0.61

Notes: CSF = cerebrospinal fluid. NfL = Neurofilament light chain. * = excluding outliers. All variables values are expressed in pg/ml.