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. 2025 Jun 19;18:3239–3251. doi: 10.2147/IJGM.S521565

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© 2025 Wang et al.

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GEO Data Processing, Differential Analysis, Enrichment Analysis, and Visualization of Differentially Expressed Genes. (A) The principal component analysis after batch effect correction. (B and C) The visualization of DEGs identified from the merged GEO datasets. Volcano plot (B) and Heatmap (C). (D) The intersection of DEGs and circadian rhythm genes. (E and F) The heatmap of these 15 intersecting genes and their correlation. (G and H) The GO terms and KEGG pathways enriched by the differentially expressed circadian rhythm genes. *p<0.05, **p<0.01, ***p<0.001.