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. 2025 Jun 19;18:3239–3251. doi: 10.2147/IJGM.S521565

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© 2025 Wang et al.

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Construction and Validation of the DSS Mouse Model. (A) Colon length of mice given 3% DSS in drinking water for 7 days. n=6 per group. (B) Body weight. n=6 per group. (C and D) Differentially expressed genes (logFC > 1 or < −1, p < 0.05) between control and DSS colons. (E) KEGG signaling pathway enrichment on top differentially expressed genes (logFC > 1 or < −1, p < 0.05). (F) Venn diagram of differentially expressed genes and genes screened by machine learning. The data were presented as the mean ± SD, with significance indicated by ****p<0.0001.