Fig. 6.
Impact of the Ross score on the maximum serum drug concentration after the first dose (Cmax,1) of enalaprilat after administration of 0.25 mg enalapril maleate. The boxplot shows the predicted Cmax,1 for subjects with a weight of 5 kg, an age of 0.34 years, a serum creatinine of 23.37 µmol/L and a Ross score between 0 and 11 (minimum to maximum Ross score of the analysed population). For each Ross score, 988 Cmax,1 values were estimated. The upper whisker extends from the 75th percentile to the largest value no further than 1.5 times the interquartile range from the 75th percentile. The lower whisker extends from the 25th percentile to the smallest value no further than 1.5 times the interquartile range from the 25th percentile. Data beyond the end of the whiskers are outliers and are shown as black dots. Cmax,1 maximum serum drug concentration after the first dose