Figure 10.

Physiological function of TRPM4 in T cells. Solid red arrows indicate calcium flow; dash arrows indicate calcium regulation targets. Solid black and deep blue arrows indicate sodium and potassium flow, respectively. Only selected ion channels are shown. CRAC, calcium release-activated calcium channel; CaM, calmodulin; p-MHC, peptide presented by major histocompatibility complex; CD4, cluster of differentiation 4; TCR, T-cell receptor; TK, tyrosine kinase; PLCγ, phosphoinositide phospholipase C γ subunit; IL-2, interleukin-2; ER, endoplasmic reticulum.