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. Author manuscript; available in PMC: 2025 Jul 1.
Published in final edited form as: Physiol Rev. 2025 Jan 15;105(3):1033–1074. doi: 10.1152/physrev.00012.2024

Figure 12.

Figure 12.

Physiological function of TRPM4 and TRPM5 in pancreas beta-cells at low (A) and high (B) blood glucose levels. Solid red arrows indicate calcium flow; dash arrows indicate calcium regulation targets. Solid black, deep blue arrows indicate sodium and potassium flow, respectively. Endoplasmic reticulum serves as an important intracellular calcium store for beta-cells but is omitted due to space limitation. Only selected ion channels are shown. GLUT-2, glucose transporter 2; G-6-P, glucose 6-phosphate.