. Author manuscript; available in PMC: 2025 Jul 1.

Published in final edited form as: Physiol Rev. 2025 Jan 15;105(3):1033–1074. doi: 10.1152/physrev.00012.2024

Table 1.

TRPM4 modulators

Molecule	EC₅₀/IC₅₀ (μM)	References
Activator / Potentiator
Intracellular Ca²⁺	0.3–1000	Colquhoun, 1981; Yellen, 1982; Launay, 2002; Nilius, 2003; Nilius, 2004; Nilius, 2005; Ullrich, 2005; Yarishkin, 2008; Sala-Rabanal, 2012; Amarouch, 2013; Yamaguchi, 2014; Winkler, 2017; Autzen, 2018; Hu, 2024
Intracellular Co²⁺ with Ca²⁺	107	Yamaguchi, 2014
Intracellular Mn²⁺ with Ca²⁺	ND	Yamaguchi, 2014
Intracellular Ni²⁺ with Ca²⁺	ND	Yamaguchi, 2014
PIP2 with Ca²⁺	4–42.2	Zhang, 2005; Nilius, 2006; Yamaguchi, 2014; Guo, 2017
BTP2	0.008	Takezawa, 2006
Decavanadate with Ca²⁺	1.9	Nilius, 2004; Winkler, 2017; Hu, 2024
Mg₂ATP	ND	Zhang, 2005; Nilius, 2006; Guo, 2017
Inhibitor
Adenosine	630	Sturgess, 1986; Nilius, 2004
AMP	19	Sturgess, 1986; Nilius, 2004
ADP	2.2	Sturgess, 1986; Nilius, 2004
ATP	0.8–2.3	Sturgess, 1986; Nilius, 2004; Guo, 2017; Arullampalam 2021; Hu, 2024
AMP-PNP	19	Thorn, 1992; Nilius, 2004
Spermine	61	Nilius, 2004
Flufenamic acid	2.8–5.5	Korbmacher, 1995; Guinamard, 2006; Demion, 2007; Morita, 2007
Clotrimazole	ND	Ullrich, 2005
Glibenclamide	ND	Guinamard, 2006; Demion, 2007; Sala-Rabanal, 2012
9-phenanthrol	10–30	Grand, 2008; Gonzales, 2010
CBA (Compound 5)	0.7–1.8	Ozhathil, 2018
NBA (Compound 6)	0.1–0.2	Ozhathil, 2018; Arullampalam, 2021

ND, not determined.