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. 2025 Jun 11;16:1595686. doi: 10.3389/fphar.2025.1595686

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Copyright © 2025 Peng, Chan, Chen, Yung, Cheung and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LHA suppresses the migration of pancreatic cancer cells. (A) The effect of LHA on the migration of pancreatic cancer cells was determined using wound-healing assay. Images were captured at two time points (0 and 24 h) after the LHA treatment. Representative photographs show the same area at time 0 to after 24-h incubation. (B,C) The genetic levels of cell migration markers, including MMP2, MMP7, MMP9, Snail, vimentin, E-cadherin, and N-cadherin, were decided using the RT-PCR. Data were expressed as mean ± S.D. of at least three independent experiments. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. control.