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. 2025 Jun 21;31(23):106949. doi: 10.3748/wjg.v31.i23.106949

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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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NLR family pyrin domain containing 3 expression in rat esophageal fibroblasts in the narrowed esophagus. A: Representative Immunofluorescence image of NLR family pyrin domain containing 3 (NLRP3) and vimentin colocalization in the healthy esophagus (control) and fibrotic esophagus (model) in rats. Scale bar = 50 μm; B: Pearson correlation coefficient of NLRP3 and vimentin in the rat esophagus (presented as mean ± SE). Statistical analysis was performed using the Student’s t test, ^aP = 0.009; C: Immunohistochemistry of vimentin and cytokeratin 19 in primary rat esophageal fibroblasts (REFs). Scale bar = 500 μm; D: Western blot analysis and mRNA levels of collagen 1 in primary REFs transfected with control or NLRP3 overexpression lentiviral particles for 72 hours (presented as mean ± SE). Statistical analysis was performed using the Student’s t test. ^bP < 0.001; ^cP = 0.003; NLRP3: NLR family pyrin domain containing 3; NC: Negative control.