Table 2.

Meta-analysis of reported outcomes

Variable	Number of participants	Mean difference (95% CI)	Effect p value	Number of studies
Pain intensity
After 1 month of treatment, appropriate blinding only	123	-0.21 (-0.72 to 0.29)	0.40	2
After 1 month of treatment, including unblinding	123	-0.44 (-0.74 to -0.13)	0.01	2
After 2 to 4 months of treatment	796	-0.38 (-0.76 to 0.00)	0.05	2
Sleep interference
After 2 to 4 months of treatment	796	-0.56 (-0.91 to -0.22)	< 0.01	2

A negative number means greater reduction in gabapentinoid than placebo group. Both pain intensity and sleep interference were measured on a scale from 0 to 10. The MCID was assumed to be -2 for pain intensity and -1.5 for sleep interference.