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[Preprint]. 2025 May 3:2025.05.02.651992. [Version 1] doi: 10.1101/2025.05.02.651992

Figure 5. TEAD1 binds to both enhancers and heterochromatin regions in the genome.

Figure 5.

(A) TEAD1 peaks were mapped back to various regions of the genome. The percentage of the TEAD1 peaks found within each region of the genome is shown in the pie chart.

(B-C) Bar graph from GREAT analysis showing the percent distribution of TEAD1 peaks in relation to the transcription start site (TSS) of genes in UOK121 (B) and UOK342 (C) cells. Distance to TSS is shown in kilobases (kb).

(D) Heatmaps showing merged TEAD1, and H3K27ac ChIP-seq signals (merged data from HK2, UOK121, UOK122, UOK342). Active enhancer regions are shown as regions that have H3K27ac peaks.

(E) Motif analysis of TEAD1-bound peaks showing the most significant M-CAT motif in 348 sites.

(F) Gene ontology analysis of TEAD1-bound peaks using DAVID.

(G) Gene tracks showing TEAD1 and YAP1 co-binding at the H3K27ac region of CTGF (left) and Cyr61 (right) genes, with their corresponding mRNA expression profiles.

(H-I) Bar graphs from GREAT analysis showing the percent distribution of TEAD1-H3K9me3 co-peaks in relation to the transcription start site (TSS) of genes in UOK121 (H) and UOK342 (I). Distance to TSS is shown in kilobases (kb).

(J) Heatmaps showing TEAD1 ChIP signals across cell lines at TEAD1/H3K9me3 co-binding regions of UOK121 (top) and UOK342 (bottom).