TABLE 2.
Coronary Atherosclerosis Quantification at Baseline According to Polygenic Risk Group
| Polygenic Risk | |||||
|---|---|---|---|---|---|
| Overall (N = 288) |
Low (n = 58) |
Intermediate (n = 172) |
High (n = 58) |
P Value | |
| Total plaque volume, mm3 | 126.3 (30.48–351.1) | 46.4 (12.4–197.4) | 128.5 (29.2–330.9) | 286.6 (86.6–530.7) | <0.001 |
| Noncalcified plaque volume, mm3 | 88.6 (27.4–233.4) | 43.4 (11.4–107.8) | 94.3 (25.1–213.5) | 187.0 (58.9–312.8) | <0.001 |
| Calcified plaque volume, mm3 | 21.7 (0.0–105.6) | 2.5 (0.0–63.9) | 15.6 (0.0–92.5) | 73.5 (18.6–225.8) | <0.001 |
| Percent atheroma volume, % | 4.9 (1.1–13.0) | 1.9 (0.5–8.1) | 4.7 (1.0–11.2) | 10.4 (3.2–18.9) | <0.001 |
| Percent noncalcified plaque volume, % | 3.4 (1.1–8.2) | 1.7 (0.5–4.9) | 3.4 (1.0–7.9) | 6.4 (2.0–11.6) | <0.001 |
| Percent calcified plaque volume, % | 0.8 (0.0–4.0) | 0.1 (0.0–2.9) | 0.7 (0.0–3.9) | 2.8 (0.7–7.5) | <0.001 |
| Presence of high-risk plaque | 111 (39) | 14 (24) | 66 (38) | 31 (53) | 0.005 |
| Presence of obstructive stenosis | 104 (36) | 10 (17) | 64 (37) | 30 (52) | 0.001 |
| CAD-RADS score | 0.003 | ||||
| 0 | 10 (3.5) | 3 (5.2) | 7 (4.1) | 0 (0) | |
| 1 | 130 (45) | 35 (60) | 77 (45) | 18 (31) | |
| 2 | 44 (15) | 10 (17) | 24 (14) | 10 (17) | |
| 3 | 38 (13) | 4 (6.9) | 19 (11) | 15 (26) | |
| 4 or 5 | 66 (23) | 6 (10) | 45 (26) | 15 (26) | |
Values are median (Q1-Q3) or n (%).
CAD-RADS = Coronary Artery Disease Reporting and Data System.