TABLE 3.

Association of CAD PRS With Baseline Plaque Volumes

	Model 1 (Unadjusted)		Model 2 (Adjusted for Age, Sex, Genetic Ancestry, and Conventional Risk Factors)
	Beta (95% CI)	P Value	Beta (95% CI)	P Value
Baseline percent atheroma volume
CAD PRS, per 1 SD increase	1.22 (0.20–2.25)	0.020	0.97 (−0.07 to 2.00)	0.069
Genetic risk groups
Low PRS	Ref.	Ref.	Ref.	Ref.
Intermediate PRS	0.51 (−2.14 to 3.16)	0.707	0.26 (−2.4 to 2.93)	0.846
High PRS	4.46 (1.24–7.68)	0.007	3.31 (0.06–6.56)	0.046
Baseline percent noncalcified plaque volume
CAD PRS, per 1 SD increase	0.54 (−0.07 to 1.15)	0.086	0.43 (−0.19 to 1.05)	0.176
Genetic risk groups
Low PRS	Ref.	Ref.	Ref.	Ref.
Intermediate PRS	0.18 (−1.40 to 1.76)	0.821	0.06 (−1.54 to 1.66)	0.939
High PRS	2.08 (0.15–4.00)	0.035	1.58 (−0.37 to 3.54)	0.114
Baseline percent calcified plaque volume
CAD PRS, per 1 SD increase	0.70 (0.19–1.22)	0.008	0.55 (0.03–1.07)	0.038
Genetic risk groups
Low PRS	Ref.	Ref.	Ref.	Ref.
Intermediate PRS	0.42 (−0.91 to 1.75)	0.493	0.31 (−1.03 to 1.65)	0.651
High PRS	2.44 (0.83–4.06)	<0.001	1.79 (0.15–3.42)	0.033

Linear regression models were created with percent atheroma volume, percent noncalcified plaque volume, and percent calcified plaque volume as dependent outcomes using both CAD PRS on a continuous scale and divided in the different genetic risk groups. The multivariable model was adjusted for age, sex, genetic ancestry, coronary revascularization, and conventional risk factors (hypertension, hypercholesterolemia, diabetes, body mass index, smoking status, family history of CAD, and statin use).

Ref. = Reference; other abbreviations as in Table 1.