TABLE 4.
Changes in Plaque Volumes Between Baseline and 10-Year Follow-Up
| Polygenic Risk | |||||
|---|---|---|---|---|---|
| Overall (N = 288) |
Low (n = 58) |
Intermediate (n = 172) |
High (n = 58) |
P Value | |
| PAV | |||||
| Absolute change, % | 2.83 (0.53–7.10) | 1.28 (0.37–3.86) | 2.73 (0.53–6.97) | 5.05 (2.06–9.44) | 0.001 |
| Above-median progression | 19 (33) | 84 (49) | 41 (71) | <0.001 | |
| Percent noncalcified plaque volume | |||||
| Absolute change, % | 0.66 (0.00–2.55) | 0.35 (−0.17to1.51) | 0.67 (0.00–2.55) | 2.10 (0.11–3.34) | 0.010 |
| Above-median progression | 20 (34) | 87 (51) | 37 (64) | 0.007 | |
| Percent calcified plaque volume | |||||
| Absolute change, % | 1.21 (0.08–3.71) | 0.42 (0.00–1.98) | 1.21 (0.07–3.73) | 1.96 (0.62–5.76) | 0.002 |
| Above-median progression | 20 (34) | 85 (49) | 39 (67) | 0.002 | |
Values are median (Q1-Q3) or n (%). Shown is the absolute change in percent atheroma volumes (PAVs) for patients with low, intermediate, and high polygenic risk score (PRS) and the proportion of patients with above-median progression for PAV, noncalcified plaque volume, and calcified plaque volume. Vessels that were revascularized between baseline and follow-up were excluded from both baseline and follow-up plaque analysis.