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. 2025 Jun 14;17(12):1988. doi: 10.3390/cancers17121988

Figure 6.

Figure 6

Conditioning cells with Evofos modified the expression of Hif-1α and cGAS/STING, as well as the gene expression of type I interferon. (A) The representative immunoblot analysis reveals alterations in Hif-1α, cGAS, and pSTINGSer366 levels following Evofos treatment in both normoxic and hypoxic conditions. Values below the blots indicate the fold change in expression, normalized to the loading control. Changes in the gene expression of type I interferon signaling genes in MCF-7 cells (B) and MDA-MB-231 cells (C) after Evofos treatment in normoxia or hypoxia, as measured 24 h after treatment. Data presented as mean ± SD; N = 3. * p < 0.05, ** p < 0.01, *** p < 0.001, NS = not significant when compared between respective treatment groups as measured by one-way ANOVA followed by Bonferroni-adjusted post hoc test.