CVD	cardiovascular disease
PCI	percutaneous coronary intervention
CABG	coronary artery bypass graft
FI	frailty index
GRACE	Global Registry for Acute Coronary Events
REPOSI	REgistro POliterapie SIMI (Registro Politerapie Società Italiana di Medicina Interna)
PRISMA	Preferred Reporting Items for Systematic Reviews and Meta-Analyses
EWAS	epigenome-wide association study
CpG	Cytosine-phosphate-Guanine
eFRS	epigenetic Frailty Risk Score
DMRs	differentially methylated regions
LINE-1	Long Interspersed Nuclear Element-1
DNAm	DNA methylation
eAA	epigenetic Age Acceleration
SASP	senescence-associated secretory phenotype
miRNA	microRNA
lncRNA	long noncoding RNA
ANRIL	antisense noncoding RNA in the INK4 locus
TLRs	toll-like receptors
NF-κB	nuclear factor kappa-light-chain-enhancer of activated B cells
IL	interleukin
TNF-α	tumor necrosis factor-alpha
TGF-β	transforming growth factor-beta
IRAK1	interleukin-1 receptor-associated kinase 1
TRAF6	TNF receptor-associated factor 6
KEGG	Kyoto Encyclopedia of Genes and Genomes
Ago2	Argonaute 2
LDL	low-density lipoprotein
HDL	high-density lipoprotein
CRP	C-reactive protein
PAI-1	plasminogen activator inhibitor-1
GDF15	growth differentiation factor 15
SI	Smoking Index
DNAmCVDscore	DNA methylation cardiovascular disease score
MAPK	mitogen-activated protein kinase
Ras	Rat sarcoma (small GTPase proteins)
mRNA	messenger RNA
AUC	area under the curve
HR	hazard ratio
OR	odds ratio