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. 2025 May 30;17(6):724. doi: 10.3390/pharmaceutics17060724
PH Pulmonary hypertension
PASMCs Pulmonary artery smooth muscle cells
ROS Reactive oxygen species
MDA Malondialdehyde
SOD Superoxide dismutase
CAT Catalase
Wog Wogonin
Wog+Alop The physical mixture of wogonin and aloperine
Wog-Alop Wogonin-aloperine co-amorphous
PDGF-BB Platelet-derived growth factor-BB
CAM Co-amorphous
API Active pharmaceutical ingredient
CCF Co-amorphous co-former
PXRD Powder X-ray diffraction
DSC Differential scanning calorimetry
FTIR Fourier transform infrared
MCT Monocrotaline
UPLC Ultra-performance liquid chromatography
UPLC-QQQ-MS Ultra-performance liquid chromatography-tandem triple quadrupole mass spectrometry
RVSP Right ventricular systolic pressure
RV Right ventricle
LV Left ventricle
S Ventricular septum
RVHI Right ventricular hypertrophy index
LMI Lung mass index
PCNA Proliferating cell nuclear antigen
DMEM Dulbecco’s modified Eagle medium
FBS Fetal bovine serum
P/S Penicillin/streptomycin
CCK-8 Cell counting kit-8
DCFH-DA 2′,7′-dichlorodihydrofluorescein diacetate
GSH Glutathione
GPx Glutathione peroxidase