Skip to main content
Journal of Cancer Research and Clinical Oncology logoLink to Journal of Cancer Research and Clinical Oncology
editorial
. 1990 Jul;116(4):318–323. doi: 10.1007/BF01612912

Application of molecular cytogenetic techniques to the evaluation of renal parenchymal tumors

Gyula Kovacs 1
PMCID: PMC12201232  PMID: 2202729

Abstract

This guest editorial discusses the molecular cytogenetic features of human renal parenchymal tumors with an emphasis on their diagnostic usefulness. Important contributions of this review are discrimination (a) between papillary and nonpapillary renal cell carcinomas and (b) between tubulopapillary adenomas and papillary carcinomas. Speculations regarding the histogenesis of different renal parenchymal tumors are presented, with the hope that they may serve to diminish some of the confusion surrounding the classification of these tumors.

Key words: Molecular cytogenetics, Kidney tumors, Classification

Abbreviations used

RCC

renal cell carcinoma

VHL

von Hippel-Lindau disease

EGFR

epidermal growth factor receptor

Footnotes

The “Journal of Cancer Research and Clinical Oncology” publishes in loose succession “Editorials” and “Guest editorials” on current and/or controversial problems in experimental and clinical oncology. These contributions represent exclusively the personal opinion of the author The Editors

By acceptance of this article, the publisher or recipient acknowledges the right of the U.S. Government to retain a nonexclusive, royalty-free license in and to any copyright covering the article. This project has been supported by a grant of the German Research Council (Ko 841/3) and at least in part with Federal funds from the Department of Health and Human Services under contract number NO-CO-74102 with Program Resources Inc. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commecial products, or organisations imply endorsement by the U.S. Government

References

  1. Albarron J, Imbert L (1903) Les tumeurs du rein. Libraires de L'Académie de Medicine, Paris [Google Scholar]
  2. Apitz K (1944) Die Geschwuelste und Gewebsmissbildungen der Nierenrinde. Virchow's Arch 311:328–359 [Google Scholar]
  3. Bargmann CI, Hung MC, Weinberg RA (1986) Theneu oncogene encodes an epidermal growth factor receptor-related protein. Nature 319:226–230 [DOI] [PubMed] [Google Scholar]
  4. Bennington JL, Beckwith JB (1975) Tumors of the kidney, renal pelvis and ureter. Atlas of tumor pathology, 2nd series. AFIP, Washington [Google Scholar]
  5. Bergerheim U, Nordenskjold M, Collins VP (1989) Deletion mapping in human renal cell carcinoma. Cancer Res 49:1390–1396 [PubMed] [Google Scholar]
  6. Bishop JM (1987) The molecular genetics of cancer. Science 235:305–311 [DOI] [PubMed] [Google Scholar]
  7. Bodmer WF, Bailey CJ, Bodmer J et al. (1987) Localisation of the gene for familial adenomatous polyposis on chromosome 5. Nature 328:614–616 [DOI] [PubMed] [Google Scholar]
  8. Carroll PR, Murty WS, Reuter V, Jhanwar S, Fair WR, Whitmore WF, Chaganti RSK (1987) Abnormalities at chromosome region 3p12-14 characterize clear cell renal carcinoma. Cancer Genet Cytogenet 26:253–259 [DOI] [PubMed] [Google Scholar]
  9. Cohen S, Carpenter G (1975) Human epidermal growth factor: isolation and chemical and biological properties. Proc Natl Acad Sci USA 72:1317–1321 [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cohen AJ, Li FP, Berg S, Marchetto DJ, Tsai S, Jacobs SC, Brown RS (1979) Hereditary renal-cell carcinoma associated with a chromosomal translocation. N Engl J Med 301:592–595 [DOI] [PubMed] [Google Scholar]
  11. Coussens L, Yang-Feng TL, Liao YC et al. (1985) Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with the neu oncogene. Science 230:1130–1139 [DOI] [PubMed] [Google Scholar]
  12. Cristol DS, McDonald JR, Emmett JL (1946) Renal adenomas in hypernephromatous kidneys: a study of their incidence, nature and relationship. J Urol 55:18–27 [DOI] [PubMed] [Google Scholar]
  13. Decker HJ, Neumann HPH, Walter TA, Sandberg AA (1988) 3p involvement in a renal cell carcinoma in von Lippel-Lindau syndrome. Cancer Genet Cytogenet 33:59–65 [DOI] [PubMed] [Google Scholar]
  14. Di Fiore PP, Pierce JH, Kraus MH et al. (1986)erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science 237:178–182 [DOI] [PubMed] [Google Scholar]
  15. Festenstein H, Garrido F (1986) MHC antigens and malignancy. Nature 322:502–506 [DOI] [PubMed] [Google Scholar]
  16. Hudziak RM, Schlessinger J, Ullrich A (1987) Increased expression of the putative growth factor receptor p185 (HER2) causes transformation and tumorigenesis of NIH3T3 cells. Proc Natl Acad Sci USA 84:7159–7163 [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Huebner K, Nowell PC, Croce CM (1989) Lineage-specific gene rearrangement/deletion: a nonconservative model. Cancer Res 49:4071–4074 [PubMed] [Google Scholar]
  18. King CR, Schimke RN, Arthur T, Davoren B, Collins D (1987) Proximal 3p deletion in renal cell carcinoma cells from a patient with von Hippel-Lindau disease. Cancer Genet Cytogenet 27:345–348 [DOI] [PubMed] [Google Scholar]
  19. Klein G (1987) The approaching era of the tumor suppressor genes. Science 238:1539–1545 [DOI] [PubMed] [Google Scholar]
  20. Klein G, Klein E (1985) Evolution of tumours and the impact of molecular oncology. Nature 319:190–195 [DOI] [PubMed] [Google Scholar]
  21. Knudson AG (1985) Hereditary cancer, oncogenes and anti-oncogenes. Cancer Res 45:1437–1443 [PubMed] [Google Scholar]
  22. Knudson AG (1987) A two mutation model for human cancer. Adv Viral Oncol 7:1–17 [Google Scholar]
  23. Kovacs G (1989) Papillary renal cell carcinoma. A morphologic and cytogenetic study of 11 cases. Am J Pathol 134:27–34 [PMC free article] [PubMed] [Google Scholar]
  24. Kovacs G, Frisch S (1989) Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell carcinomas. Cancer Res 49:651–659 [PubMed] [Google Scholar]
  25. Kovacs G, Szucs S, DeRiese W, Baumgartel H (1987a) Specific chromosome aberration in human renal cell carcinoma. Int J Cancer 40:171–178 [DOI] [PubMed] [Google Scholar]
  26. Kovacs G, Szucs S, Eichner W, Maschek HJ, Wahnschaffe U, DeRiese W (1987b) Renal oncocytoma. A cytogenetic and morphologic study. Cancer 59:2071–2077 [DOI] [PubMed] [Google Scholar]
  27. Kovacs G, Erlandsson R, Boldog F, Ingvarsson S, Muller-Brechlin R, Klein G, Sumegi J (1988) Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma. Proc Natl Acad Sci USA 85:1571–1575 [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Kovacs G, Brusa P, DeRiese W (1989a) Tissue-specific expression of a constitutional 3;6 translocation: development of multiple bilateral renal cell carcinomas. Int J Cancer 43:422–427 [DOI] [PubMed] [Google Scholar]
  29. Kovacs G, Wilkens L, Papp T, DeRiese W (1989b) Differentiation between papillary and nonpapillary renal cell carcinomas by DNA analysis. J Natl Cancer Inst 81:527–530 [DOI] [PubMed] [Google Scholar]
  30. Kovacs G, Welter K, Wilkens L, Blin N, DeRiese W (1989c) Renal oncocytoma. A phenotypic and genotypic entity of renal parenchymal tumors. Am J Pathol 134:967–971 [PMC free article] [PubMed] [Google Scholar]
  31. Kuliev AM, Kuharenko VI, Grinberg KN et al. (1973) Morphological, autoradiographic, immunochemical and cytochemical investigations of a cell strain with trisomy 7 from a spontaneous abortus. Humangenetik 17:285–296 [DOI] [PubMed] [Google Scholar]
  32. Leppert M, Dobbs M, Scambler P et al. (1987) The gene for familial polyposis coli maps to the long arm of chromosome 5q. Science 238:1411–1413 [DOI] [PubMed] [Google Scholar]
  33. Li FP, Marchetto D, Brown RS (1982) Familial renal carcinoma. Cancer Genet Cytogenet 7:271–275 [DOI] [PubMed] [Google Scholar]
  34. Mancilla-Jimenez R, Stanley RJ, Blath RA (1986) Papillary renal cell carcinoma: a clinical, radiologic, and pathologic study of 34 cases. Cancer 38:2469–2480 [DOI] [PubMed] [Google Scholar]
  35. Marquardt H, Hunkapiller MW, Hood LF (1983) Transforming growth factors produced by retrovirus transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor. Proc Natl Acad Sci USA 80:4684 [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. McKusick VA (1986) Mendelian inheritance in man, 7th edn. John Hopkins University Press, Baltimore [Google Scholar]
  37. Muller R (1986) Cellular and viralfos genes: structure, regulation of expression, and biological properties of their encoded products. Biochim Biophys Acta 823:207–225 [DOI] [PubMed] [Google Scholar]
  38. Orain I, Buzelin F, Ferry N (1987) Tubulopapillary tumours of the kidney. Apropos of 20 new cases and a review of the literature. J Urol 93:1–9 [PubMed] [Google Scholar]
  39. Pathak S, Strong LC, Ferrell RE, Trindade A (1982) Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells. Science 217:939–941 [DOI] [PubMed] [Google Scholar]
  40. Psihramis KE, Dal Cin P, Dretler SP, Prout GR, Sandberg AA (1988) Further evidence that renal oncocytoma has malignant potential. J Urol 139:585–587 [DOI] [PubMed] [Google Scholar]
  41. Seizinger BR, Rouleau GA, Ozelius LJ et al. (1988) Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature 332:268–269 [DOI] [PubMed] [Google Scholar]
  42. Slamon DJ, Clark GM, Wong SG et al. (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177–182 [DOI] [PubMed] [Google Scholar]
  43. Solomon E, Voss R, Hall V et al. (1987) Chromosome 5 allele loss in human colorectal carcinomas. Nature 328:616–619 [DOI] [PubMed] [Google Scholar]
  44. Stanbridge EJ, Flandermeyer RR, Daniels DW, Nelson-Rees WA (1981) Specific chromosome loss associated with the expression of tumorigenicity in human hybrids. Somatic Cell Genet 7:699–712 [DOI] [PubMed] [Google Scholar]
  45. Tory K, Brauch H, Linehan M et al. (1989) Specific genetic change in tumors associated with von Hippel-Lindau Disease. J Natl Cancer Inst 81:1097–1101 [DOI] [PubMed] [Google Scholar]
  46. Vogel F, Motulsky AG (1986) Human genetics. Problems and approaches, 2nd edn. Springer, Berlin Heidelberg New York [Google Scholar]
  47. Zbar B, Brauch H, Talmadge C, Linehan M (1987) Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 327:721–724 [DOI] [PubMed] [Google Scholar]
  48. Yamamoto T, Ikawa S, Akiyama T et al. (1986) Similarity of protein encoded by the human c-erbB-2 gene to epidermal growth factor receptor. Nature 319:230–234 [DOI] [PubMed] [Google Scholar]
  49. Yurov YB (1978) Replication of chromosomal DNA in cultured abnormal human cells. Hum Genet 43:47–52 [DOI] [PubMed] [Google Scholar]

Articles from Journal of Cancer Research and Clinical Oncology are provided here courtesy of Springer

RESOURCES