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. 2025 Jun 13;17:1537413. doi: 10.3389/fnagi.2025.1537413

Table 2.

The weighted association of separated gait speed, processing speed (DSST) and CMD mortality.

Models Cardiometabolic disease mortality
aDeath no. /total no. HR (95%CI) p-value
Gait speed Normal gait Slow gait
Crude model 325/1772 262/710 2.4 (1.98, 2.90) <0.001
Model 1 325/1772 262/710 1.73 (1.43, 2.08) <0.001
Model 2 325/1772 262/710 1.56 (1.29, 1.89) <0.001
Model 3 325/1772 262/710 1.47 (1.21, 1.80) <0.001
Processing speed (DSST) High DSST Low DSST
Crude model 235/1248 352/1234 1.81 (1.55, 2.10) <0.001
Model 1 235/1248 352/1234 1.16 (0.95, 1.43) 0.138
Model 2 235/1248 352/1234 1.09 (0.89, 1.33) 0.865
Model 3 235/1248 352/1234 1.01 (0.82, 1.22) 0.983
a

Death and total number of participants are presented as unweighted number.

DSST, Digit Symbol Substitution Test, a cognitive test of processing speed; CMD, cardiometabolic disease; HR, hazard ratio; CI, confidence interval. Model 1 was adjusted for age, sex, education, poverty income ratio (PIR); Model 2 was additionally adjusted for physical activity, balance, smokers, alcohol use, CRP and history of cancer; Model 3 was further adjusted for the history of cardiovascular and cerebrovascular diseases (CVD) and cardiometabolic disease risk factors (CMDRF).