Table 2.
Results of genetic and nutritional factor association analysis.
| SNP gene | SNP variant | Genotype distribution (OA patients) | Genotype distribution (control group) | p-value | Average Omega-3 Intake (g/day) in OA (GG Genotype) | Average Omega-3 Intake (g/day) in Control (GG Genotype) | p-value | Vitamin D Intake (IU/day) in OA (TT Genotype) | Vitamin D Intake (IU/day) in Control (TT Genotype) | p-value | Average Vitamin C Intake (mg/day) in OA (GG Genotype) | Average Vitamin C Intake (mg/day) in Control (GG Genotype) | p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FADS1 (Fatty Acid Desaturase) | rs174537 | 45% GG | 30% GG | 0.012 | 1.1 (SD = 0.5) | 2.0 (SD = 0.8) | 0.006 | – | – | – | – | – | – |
| VDR (Vitamin D Receptor) | rs2228570 | 30% TT | 20% TT | 0.009 | – | – | – | 310 (SD = 120) | 450 (SD = 200) | 0.002 | – | – | – |
| IL-6 (Interleukin 6) | rs1800795 | 40% GG | 25% GG | 0.015 | – | – | – | – | – | – | 60 (SD = 30) | 85 (SD = 40) | 0.003 |
| SNP gene (variant) | Genotype | OA patients (%) | Control group (%) | p-value | OR (95% CI) | Average nutrient intake in OA (genotype) | Average nutrient intake in control (genotype) | p-value |
|---|---|---|---|---|---|---|---|---|
| FADS1(rs174537) | GG | 45 | 30 | 0.012 | 1.89(115–3.10) | Omega-3: 1.1 g/day (SD = 0.5) | Omega-3:2.0 g/day (SD = 0.8) | 0.006 |
| VDR (rs2228570) | TT | 30 | 20 | 0.009 | 171(1.14–2.56) | Vitamin D: 310 IU/day (SD = 120) | Vitamin D:450 IU/day (SD = 200) | 0.002 |
| IL-6(rs1800795) | GG | 40 | 25 | 0.015 | 1.98(123–319) | Vitamin C:60 mg/day (SD = 30) | Vitamin C:85 mg/day (SD = 40) | 0.003 |
Data Source: Data for genetic variants and nutrient intake based on 500 participants, with statistical analysis including genotype frequencies and mean nutrient intake levels for each group. Standard deviations (SD) are included for nutritional intake data. The associations for FADS1 rs174537 and VDR (Vitamin D receptor) rs2228570 did not reach the genome-wide significance threshold and represent candidate gene findings.