Table 2.
Reactome gene sets within the MARS signatures.
| Correlation with RHI score (r) | C2-CP:Reactome gene set | Parent pathway | Subpathway 1 | Subpathway 2 | Subpathway 3 | GSEA-MSigDB Link |
|---|---|---|---|---|---|---|
| 0.46 | Regulation of IFNα signaling | Immune system | Cytokine signaling in immune system | Interferon signaling | Interferon-alpha/beta signaling | https://reactome.org/content/detail/R-HSA-912694 |
| 0.45 | IL-4 and IL-13 signaling | Immune system | Cytokine signaling in immune system | Signaling by interleukins | https://reactome.org/content/detail/R-HSA-6785807 | |
| 0.42 | Platelet adhesion to exposed collagen | Hemostasis | https://reactome.org/content/detail/R-HSA-75892 | |||
| 0.41 | Potential therapeutics for SARS | Disease | Infectious disease | SARS-COV infections | https://reactome.org/content/detail/R-HSA-9679191 | |
| 0.40 | Tryptophan catabolism | Metabolism | Metabolism of amino acids and derivatives | https://reactome.org/content/detail/R-HSA-71240 | ||
| 0.40 | UPR | Cellular responses to stimuli | Cellular responses to stress | https://reactome.org/content/detail/R-HSA-381119 | ||
| –0.42 | Aspartate and asparagine metabolism | Metabolism | Metabolism of amino acids and derivatives | https://reactome.org/content/detail/R-HSA-8963693 | ||
| –0.41 | Branched-chain amino acid catabolism | Metabolism | Metabolism of amino acids and derivatives | https://reactome.org/content/detail/R-HSA-70895 | ||
| –0.43 | Regulation of FZD by ubiquitination | Signal transduction | Signaling by WNT | TCF dependent signaling in response to WNT | https://reactome.org/content/detail/R-HSA-4641263 | |
| –0.44 | Sulfur amino acid metabolism | Metabolism | Metabolism of amino acids and derivatives | https://reactome.org/content/detail/R-HSA-1614635 | ||
| –0.48 | Peroxisomal protein import | Protein localization | https://reactome.org/content/detail/R-HSA-9033241 |
Abbreviations: C2, curated gene sets; CP, canonical pathway; FZD, frizzled receptor; IFNα, interferon-alpha; IL, interleukin; RHI, Robarts Histopathology Index; SARS, severe acute respiratory syndrome; SARS-COV, SARS coronavirus; TCF, T-cell factor; UPR, unfolded protein response; WNT, wingless-type MMTV integration site family.