TABLE 3.
Regulation and regression analysis of anchor parent‐offspring relationships in chronic kidney disease (CKD).
| Offspring | Fold change | Parent | Fold change | HEALTHY slope | CKD slope | Slope change |
|---|---|---|---|---|---|---|
| Anchor 1 | 1.12* | Parent of anchor 1 | 0.67* | 2.258* | 3.221* | 0.962 |
| Offspring of anchor 1 | 1.11 | Anchor 1 | 1.12* | 0.013* | 0.016* | 0.003 |
| Anchor 2 | 0.88* | Parent of anchor 2 | 0.93* | 1.171* | 1.045* | −0.126 |
| Offspring of anchor 2 | 0.73* | Anchor 2 | 0.88* | 0.033* | 0.050* | 0.017 |
| Anchor 3 | 1.06 | Parent of anchor 3 | 0.81* | 7.277* | 5.533* | −1.744 |
| Offspring of anchor 3 | 1.59* | Anchor 3 | 1.06 | 0.064* | 0.072* | 0.008 |
| Anchor 4 | 0.96 | Parent of anchor 4 | 1.29* | 14.844* | 9.443* | −5.402 |
| Offspring of anchor 4 | 0.99 | Anchor 4 | 0.96 | 0.094* | 0.116* | 0.022 |
| Anchor 5 | 0.69* | Parent of anchor 5 | 0.94 | 3.740* | 1.934* | −1.806 |
| Offspring of anchor 5 | 0.68* | Anchor 5 | 0.69* | 0.212* | 0.324* | 0.112 |
| Anchor 6 | 1.05 | Parent of anchor 6 | 0.95* | 5.326* | 3.977* | −1.349 |
| Offspring of anchor 6 | 1.07 | Anchor 6 | 1.05 | 0.260* | 0.262* | 0.002 |
| Anchor 7 | 1.08 | Parent of anchor 7 | 0.57* | 11.374* | 10.092* | −1.283 |
| Anchor 8 | 0.72* | Parent of anchor 8 | 0.54* | 6.862* | 5.932* | −0.930 |
| Offspring of anchor 8 | 0.74* | Anchor 8 | 0.72* | 0.466* | 0.520* | 0.054 |
| Anchor 9 | 0.63* | Parent of anchor 9 | 0.43* | 8.381* | 8.768* | 0.387 |
| Offspring of anchor 9 | 0.85* | Anchor 9 | 0.63* | 0.579* | 0.327* | −0.252 |
| Anchor 10 | 0.92* | Parent of anchor 10 | 0.53* | 2.439* | 2.804* | 0.366 |
| Offspring of anchor 10 | 0.85* | Anchor 10 | 0.92* | 0.436* | 0.453* | 0.017 |
Note: Each row represents a potential relationship between an offspring peptide and its parent peptide, selected from the most likely relationships involving the anchor peptides. The table shows the regulation of both parent and offspring peptides in CKD (CKD vs. Control patients, n = 612, each) and regression analysis slope between the parent and offspring peptide in each relationship in healthy (n = 1131) and CKD (n = 5585) samples. Fold changes are calculated by dividing the average value of peptide intensity in cases and average value of peptide intensity in controls. Slope changes are calculated by subtracting the healthy slope from the CKD slope. Significant fold changes and slopes (p < 0.05, Benjamini–Hochberg adjustment) are marked with an asterisk.