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. 2025 Jun 24;20:8101–8118. doi: 10.2147/IJN.S516233

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© 2025 Jiang et al.

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Pharmacokinetics and pharmacodynamics. Concentrations of pralidoxime chloride in the brain homogenate (A) and serum (B); activities of AChE in brain homogenate (C) and serum (D); reactivation rates of AChE in brain homogenate (E) and serum (F) at different times after the intravenous tail vein injection; n=5 (due to mouse death, the sample size for the 0.9% NaCl group at the 12 h and 24 h time points was 3, and that for the PAM group at 12 h was 4). Compared with the PAM group,#p<0.05,##p<0.01,###p<0.001, and ####p<0.0001. Compared with the PAM-SiO₂ group, *p<0.05, **p<0.01, ***p<0.001, and ****p<0.0001. No significant difference was detected if not indicated.