Table 5.

Hydrodynamic diameter and HAp binding efficiency of self-assembling NPs (Bisphosphonate name Alendronate)

Carrier type	Carrier composition	Hydrodynamic diameter, nm	In vitro HAp binding efficiency, %	Ref.
Lipid-based NP	DOPA, DOPC, OSA, PEG	>65	>40 in 1 h	[43]
	DOPA, DOPC, OSA, Cholesterol, PEG	>61	>20 in 1 h	[47]
	DOPA, DOPC, OSA, cholesterol, PEG	>65	Less than 15 in 2 h	[48]
	SPC, cholesterol, DDAB, PEG-S	>106	Over 80 in 1 h	[46]
Polymeric micelle	PEG, PLL	>63	>60 in 1 h	[42]
	Pullulan, PEG, PTX	>70	Over 40 in 1 h	[49]
	PEG, DOX	>114	>70 in 15 min	[41]
	Acetic anhydride, curcumin	161	>55 in 1 h	[50]