Table 3.
The estimated effects of efficacy (y1) and safety (y2) outcomes in the meta-analysis of antidepressant drugs using unadjusted, univariate and proposed bivariate T&F approaches. Larger effects favor treatment over control. Presented are the OR estimates of the two outcomes and 95% CI, or the numbers of trim and filled studies and their standard errors. The T&F method is conducted on the arcsine-difference scale and the OR is then calculated based on the filled studies.
| Method | Published | Published + grey literature | ||||
|---|---|---|---|---|---|---|
| y1 (95% CI) | y2 (95% CI) | k0 (SE) | y1 (95% CI) | y2 (95% CI) | k0 (SE) | |
| Unadjusted | 1.737 (1.663, 1.813) | 0.979 (0.934, 1.026) | NA | 1.631 (1.571, 1.693) | 1.003 (0.964, 1.043) | NA |
| Univariate T&F, R0 | 1.718 (1.645, 1.793) | 1.008 (0.960, 1.059) |
y1: 3 (2.8) y2: 7 (4.0) |
1.602 (1.540, 1.666) | 0.978 (0.933, 1.025) |
y1: 4 (3.2) y2: 8 (4.2) |
| Bivariate T&F, R0 | 1.718 (1.645, 1.793) | 1.008 (0.960, 1.059) | 7 (4.0) | 1.614 (1.552, 1.679) | 0.984 (0.944, 1.025) | 8 (4.2) |
| Univariate T&F, L0 | 1.557 (1.486, 1.632) | 0.959 (0.915, 1.005) |
y1: 49 (11.1) y2: 27 (10.8) |
1.539 (1.485, 1.594) | 0.909 (0.871, 0.949) |
y1: 52 (12.6) y2: 53 (12.6) |
| Bivariate T&F, L0 | 1.565 (1.493, 1.641) | 0.959 (0.915, 1.005) | 49 (11.1) | 1.576 (1.519, 1.636) | 0.912 (0.874, 0.952) | 54 (12.6) |