Table 5.
Hazard Ratios of POAG among T2DM with Different DM Drug User
| Variable | POAG |
Crude |
Adjusted∗ |
||||
|---|---|---|---|---|---|---|---|
| n | PY | IR | HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Metformin user | 5788 | 1 564 830.05 | 3.70 | 1.00 (reference) | - | 1.00 (reference) | - |
| DPP4i user | 3159 | 1 759 130.36 | 1.80 | 0.48 (0.46, 0.50)§ | <0.001 | 0.55 (0.53, 0.58)§ | <0.001 |
| SU user | 5048 | 1 249 983.76 | 4.04 | 1.00 (reference) | - | 1.00 (reference) | - |
| DPP4i user | 3159 | 1 759 130.36 | 1.80 | 0.44 (0.42, 0.46)§ | <0.001 | 0.45 (0.43, 0.47)§ | <0.001 |
| TZD user | 1518 | 333 211.13 | 4.56 | 1.00 (reference) | - | 1.00 (reference) | - |
| DPP4i user | 3159 | 1 759 130.36 | 1.80 | 0.39 (0.37, 0.42)§ | <0.001 | 0.42 (0.39, 0.45)§ | <0.001 |
| AGI user | 1321 | 284 857.21 | 4.64 | 1.00 (reference) | - | 1.00 (reference) | - |
| DPP4i user | 3159 | 1 759 130.36 | 1.80 | 0.39 (0.36, 0.41)§ | <0.001 | 0.43 (0.40, 0.46)§ | <0.001 |
| Glinide user | 187 | 55 475.45 | 3.37 | 1.00 (reference) | - | 1.00 (reference) | - |
| DPP4i user | 3159 | 1 759 130.36 | 1.80 | 0.50 (0.43, 0.58)§ | <0.001 | 0.53 (0.46, 0.62)§ | <0.001 |
AGI = α-glucosidase inhibitor; CI = confidence interval; DM = diabetes mellitus; DPP4i = dipeptidyl peptidase-4 inhibitor; HR = hazard ratio; IR = incidence rate per 1000 person-years; POAG = primary open angle glaucoma; PY = person-years; SU = sulfonylurea; T2DM = type 2 diabetes mellitus; TZD = thiazolidinedione.
∗
Adjusted HR: adjusted by sex, age, region of dwelling, degree of urbanization, insurance premium, comorbidities, CCI score, and medication.
§
P < 0.001.