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. 2025 May 22;13(7):e02296-24. doi: 10.1128/spectrum.02296-24

Fig 4.

Histological sections present skin layers with epidermal ulceration, infiltrating inflammatory cells, vascular structures, necrosis, and cellular damage along upper dermis.

Microscopic images from eye lesions in semi-domesticated Eurasian tundra reindeer (Rangifer t. tarandus) infected with cervidpoxvirus. Microscopic images from eye lesion in reindeer No-22-80-P92. (A) Hematoxylin and eosin-stained section shows degenerated epithelium with vacuolization and necrosis in the epidermis (arrows). Microscopic image (B) from section stained with probe V-DPV-C1 using RNAscope in situ hybridization technique shows positive signals in the cytoplasm of epithelial cells of inflamed and degenerative epithelium, here seen as bright red stain (arrowheads). Bar 100 µm.