Table 1.

Expression of subtype-defining markers in 135 Extensive-SCLC patients

Markers	Total cases with positive expression N(%)	H-score Range N(%)
		>10–50	>50–150	>150
ASCL1(SCLC-A)	82(60.7%)	35(42.7%)	27(32.9%)	20(24.4%)
NEUROD1(SCLC-N)	39(28.9%)	18(46.1%)	12(30.8%)	9(23.1%)
POU2F3(SCLC-P)	10(7.4%)	6(60.0%)	3(30.0%)	1(10.0%)
Inflamed(SCLC-I)	25(18.5%)	-	-	-

SCLC-A: 61 patients expressing only ASCL1 and 21 patients expressing both ASCL1 and NEUROD1; SCLC-N: 18 patients expressing only NEUROD1 and 21 co-expressing ASCL1 and NEUROD1