Table 2.

AUROC across 2-year endpoints and cohort for the obtained radiomics models alongside p-value of one-sided permutation tests with alternative hypothesis of superiority of MIL models over radiomics models

Endpoint	Cohort	AUROC [95% CI] 2D MIL	AUROC [95% CI] radiomics	p-value
2-year OS	RADCURE test	0.75 [0.69–0.80]	0.74 [0.68–0.80]	0.50
2-year OS	HN1	0.77 [0.68–0.85]	0.74 [0.64–0.85]	0.50
2-year OS	HN-PET-CT	0.84 [0.77–0.90]	0.68 [0.56–0.79]	0.012
2-year LRC	RADCURE test	0.75 [0.68–0.81]	0.69 [0.62–0.76]	0.15
2-year LRC	HN1	0.66 [0.52–0.78]	0.74 [0.61–0.84]	0.84
2-year LRC	HN-PET-CT	0.72 [0.61–0.80]	0.64 [0.53–0.74]	0.15
2-year FFDM	RADCURE test	0.78 [0.71–0.84]	0.71 [0.64–0.77]	0.21
2-year FFDM	HN1	0.75 [0.55–0.92]	0.68 [0.52–0.83]	0.48
2-year FFDM	HN-PET-CT	0.71 [0.59–0.80]	0.67 [0.66–0.79]	0.53