Table 7.

Publication of different main topics over time.

Main topic	Period I (1991–2000) (n = 28)	Period II (2001–2010) (n = 49)	p- value	Period III (2011–2020) (n = 23)	p- value
Epidemiology	5 (17.9)	6 (12.2)	0.498	4 (17.4)	0.965
Non-operative diagnosis	0 (0)	1 (2.0)	0.447	0 (0)	–
Preoperative evaluation	0 (0)	6 (12.2)	0.054	0 (0)	–
Outcomes prediction	2 (7.1)	2 (4.1)	0.560	2 (8.7)	0.837
Surgery	20 (71.4)	12 (24.5)	<0.001∗	1 (4.3)	<0.001∗
Locoregional treatment	0 (0)	5 (10.2)	0.080	0 (0)	–
Adjuvant therapy	0 (0)	3 (6.1)	0.182	6 (26.1)	0.004∗
Systemic therapy	0 (0)	12 (24.5)	0.004∗	7 (30.4)	0.002∗
Management	1 (3.6)	2 (4.1)	0.911	3 (13.0)	0.211

∗p < 0.05.