Table 2.
Demographic and clinical features of all participants based on CSVD burden severity.
| Variable | Total (n = 212) | Mild CSVD burden group (n = 115) | Severe CSVD burden group (n = 97) | p-value |
|---|---|---|---|---|
| Age, median (IQR), year | 67.0 (58–73) | 65.0 (55–72) | 70.0 (64–75) | < 0.001* |
| Sex (male), n (%) | 128 (60.4) | 61 (53.0) | 67 (69.1) | 0.017* |
| Education, median (IQR), year | 9 (6–12) | 9 (9–12) | 9 (6–12) | 0.006* |
| BMI, median (IQR), kg/m2 | 24.79 (23.12–26.49) | 24.98 (22.86–26.49) | 24.44 (23.14–26.56) | 0.884 |
| Current smoking, n (%) | 46 (21.7) | 22 (19.1) | 24 (24.7) | 0.323 |
| Alcohol use, n (%) | 36 (17.0) | 15 (13.0) | 21 (21.6) | 0.096 |
| Hypertension, n (%) | 130 (61.3) | 55 (47.8) | 75 (77.3) | < 0.001* |
| SBP, median (IQR), mmHg | 138 (125–149) | 135 (121–146) | 140 (130–159) | 0.001* |
| DBP, median (IQR), mmHg | 81 ± 12.1 | 79 ± 11.7 | 84 ± 12.2 | 0.006* |
| Diabetes | 64 (30.2) | 28 (24.3) | 36 (37.1) | 0.044* |
| Coronary heart disease, n (%) | 31 (14.6) | 16 (13.9) | 15 (15.5) | 0.750 |
| History of stroke | 67 (31.6) | 25 (21.7) | 42 (43.3) | 0.001* |
| Monocyte counts | 0.34 (0.27–0.42) | 0.33 (0.26–0.42) | 0.35 (0.28–0.43) | 0.297 |
| TC, median (IQR), mmol/L | 4.20 ± 1.09 | 4.35 ± 1.09 | 4.01 ± 1.07 | 0.024* |
| TG, median (IQR), mmol/L | 1.11 (0.78–1.45) | 1.08 (0.77–1.42) | 1.14 (0.82–1.52) | 0.358 |
| HDL, median (IQR), mmol/L | 1.15 (0.97–1.36) | 1.18 (1.05–1.44) | 1.08 (0.91–1.29) | 0.002* |
| LDL, median (IQR), mmol/L | 2.56 ± 0.79 | 2.67 ± 0.83 | 2.48 ± 0.75 | 0.066 |
| Uric acid, median (IQR), umol/L | 292.00 (235.20–355.20) | 292.60 (233.50–350.10) | 290.80 (238.40–363.05) | 0.524 |
| Serum tHcy, median (IQR), umol/L | 13.20 (10.00–17.40) | 12.40 (9.80–16.00) | 14.2 (10.60–18.35) | 0.024* |
| FPG, median (IQR), mmol/L | 5.35 (4.84–6.31) | 5.25 (4.85–6.00) | 5.47 (4.80–6.67) | 0.147 |
| MHR, median (IQR) | 0.302 (0.232–0.414) | 0.296 (0.223–0.377) | 0.352 (0.247–0.469) | 0.001* |
| MMSE score | 24 (19–27) | 26 (23–28) | 21 (16–24) | < 0.001* |
*p < 0.05. SD, standard deviation; IQR, interquartile range; BMI, Body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; TC, total cholesterol; TG, triglyceride; HDL, high density lipoprotein; LDL, low density lipoprotein; tHcy, total homocysteine; MHR, monocyte to high-density lipoprotein cholesterol ratio; CSVD, cerebral small vessel disease; MMSE, Mini-Mental State Examination.